选中"Security"，在界面中勾选"Enable ClickOnce Security Settings"后，在Properties下就有自动生成app.manifest文件。
打开app.manifest文件，将
<requestedExecutionLevel level="asInvoker" uiAccess="false" />
改为
<requestedExecutionLevel level="requireAdministrator" uiAccess="false" />
<?xml version="1.0" encoding="utf-8"?>
<asmv1:assembly manifestVersion="1.0" xmlns="urn:schemas-microsoft-com:asm.v1" xmlns:asmv1="urn:schemas-microsoft-com:asm.v1" xmlns:asmv2="urn:schemas-microsoft-com:asm.v2" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<assemblyIdentity version="1.0.0.0" name="MyApplication.app" />
<trustInfo xmlns="urn:schemas-microsoft-com:asm.v2">
<security>
<requestedPrivileges xmlns="urn:schemas-microsoft-com:asm.v3">
<!-- UAC Manifest Options
If you want to change the Windows User Account Control level replace the
requestedExecutionLevel node with one of the following.
<requestedExecutionLevel level="asInvoker" uiAccess="false" />
<requestedExecutionLevel level="requireAdministrator" uiAccess="false" />
<requestedExecutionLevel level="highestAvailable" uiAccess="false" />
If you want to utilize File and Registry Virtualization for backward
compatibility then delete the requestedExecutionLevel node.
-->
<requestedExecutionLevel level="requireAdministrator" uiAccess="false" />
</requestedPrivileges>
<applicationRequestMinimum>
<defaultAssemblyRequest permissionSetReference="Custom" />
<PermissionSet class="System.Security.PermissionSet" version="1" Unrestricted="true" ID="Custom" SameSite="site" />
</applicationRequestMinimum>
</security>
</trustInfo>
</asmv1:assembly>
<asmv1:assembly manifestVersion="1.0" xmlns="urn:schemas-microsoft-com:asm.v1" xmlns:asmv1="urn:schemas-microsoft-com:asm.v1" xmlns:asmv2="urn:schemas-microsoft-com:asm.v2" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<assemblyIdentity version="1.0.0.0" name="MyApplication.app" />
<trustInfo xmlns="urn:schemas-microsoft-com:asm.v2">
<security>
<requestedPrivileges xmlns="urn:schemas-microsoft-com:asm.v3">
<!-- UAC Manifest Options
If you want to change the Windows User Account Control level replace the
requestedExecutionLevel node with one of the following.
<requestedExecutionLevel level="asInvoker" uiAccess="false" />
<requestedExecutionLevel level="requireAdministrator" uiAccess="false" />
<requestedExecutionLevel level="highestAvailable" uiAccess="false" />
If you want to utilize File and Registry Virtualization for backward
compatibility then delete the requestedExecutionLevel node.
-->
<requestedExecutionLevel level="requireAdministrator" uiAccess="false" />
</requestedPrivileges>
<applicationRequestMinimum>
<defaultAssemblyRequest permissionSetReference="Custom" />
<PermissionSet class="System.Security.PermissionSet" version="1" Unrestricted="true" ID="Custom" SameSite="site" />
</applicationRequestMinimum>
</security>
</trustInfo>
</asmv1:assembly>
然后在"Security"中再勾去"Enable ClickOnce Security Settings"后，重新编译即可。
